Nutrients (Dec 2021)
Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer
- Ziling Mao,
- Elom K. Aglago,
- Zhiwei Zhao,
- Casper Schalkwijk,
- Li Jiao,
- Heinz Freisling,
- Elisabete Weiderpass,
- David J. Hughes,
- Anne Kirstine Eriksen,
- Anne Tjønneland,
- Gianluca Severi,
- Joseph Rothwell,
- Marie-Christine Boutron-Ruault,
- Verena Katzke,
- Rudolf Kaaks,
- Matthias B. Schulze,
- Anna Birukov,
- Vittorio Krogh,
- Salvatore Panico,
- Rosario Tumino,
- Fulvio Ricceri,
- H. Bas Bueno-de-Mesquita,
- Roel C. H. Vermeulen,
- Inger T. Gram,
- Guri Skeie,
- Torkjel M. Sandanger,
- J. Ramón Quirós,
- Marta Crous-Bou,
- Maria-Jose Sánchez,
- Pilar Amiano,
- María-Dolores Chirlaque,
- Aurelio Barricarte Gurrea,
- Jonas Manjer,
- Ingegerd Johansson,
- Aurora Perez-Cornago,
- Mazda Jenab,
- Veronika Fedirko
Affiliations
- Ziling Mao
- Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
- Elom K. Aglago
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France
- Zhiwei Zhao
- Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
- Casper Schalkwijk
- Department of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University, 6229ER Maastricht, The Netherlands
- Li Jiao
- Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
- Heinz Freisling
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France
- Elisabete Weiderpass
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France
- David J. Hughes
- Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland
- Anne Kirstine Eriksen
- Danish Cancer Society Research Center, Diet, Genes and Environment Nutrition and Biomarkers (NAB), Strandboulevarden 49, DK-2100 Copenhagen, Denmark
- Anne Tjønneland
- Danish Cancer Society Research Center, Diet, Genes and Environment Nutrition and Biomarkers (NAB), Strandboulevarden 49, DK-2100 Copenhagen, Denmark
- Gianluca Severi
- CESP (UMR1018), Faculté de Médecine Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, France
- Joseph Rothwell
- CESP (UMR1018), Faculté de Médecine Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, France
- Marie-Christine Boutron-Ruault
- CESP (UMR1018), Faculté de Médecine Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, France
- Verena Katzke
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Rudolf Kaaks
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Matthias B. Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Anna Birukov
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
- Vittorio Krogh
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian, 20133 Milan, Italy
- Salvatore Panico
- Dipartmento Di Medicina Clinica E Chirurgia, Federico II University, 80131 Naples, Italy
- Rosario Tumino
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, Italy
- Fulvio Ricceri
- Department of Clinical and Biological Sciences, University of Turin, 10043 Turin, Italy
- H. Bas Bueno-de-Mesquita
- Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands
- Roel C. H. Vermeulen
- Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, 80178 Utrecht, The Netherlands
- Inger T. Gram
- Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9010 Tromsø, Norway
- Guri Skeie
- Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9010 Tromsø, Norway
- Torkjel M. Sandanger
- Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9010 Tromsø, Norway
- J. Ramón Quirós
- Public Health Directorate, 33080 Asturias, Spain
- Marta Crous-Bou
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)—Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
- Maria-Jose Sánchez
- Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain
- Pilar Amiano
- Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, 20013 San Sebastian, Spain
- María-Dolores Chirlaque
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
- Aurelio Barricarte Gurrea
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
- Jonas Manjer
- Department of Surgery, Skåne University Hospital Malmö, Lund University, SE-221 00 Malmö, Sweden
- Ingegerd Johansson
- Department of Epidemiology and Clinical Medicine, Umeå University, SE-901 87 Umeå, Sweden
- Aurora Perez-Cornago
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
- Mazda Jenab
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France
- Veronika Fedirko
- Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
- DOI
- https://doi.org/10.3390/nu13124435
- Journal volume & issue
-
Vol. 13,
no. 12
p. 4435
Abstract
Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
Keywords
- advanced glycation end-products
- dietary advanced glycation end-products
- all-cause mortality
- colorectal cancer mortality
