Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers

• Lin Yang,
• Hua Bao,
• Xue Wu,
• Yong Wu,
• Yang Shao,
• Jiani C Yin,
• Jieer Ying,
• Xiangdong Cheng,
• Guojie Xia,
• Minyan Xing,
• Xiaoxi Chen,
• Jiaohui Pang,
• Lingjun Zhu

Affiliations

Lin Yang

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Hua Bao

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Xue Wu

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Yong Wu

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Yang Shao

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Jiani C Yin

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Jieer Ying

Department of Abdominal Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China

Xiangdong Cheng

Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China

Guojie Xia

Department of Medical Oncology, Traditional Chinese Medical Hospital of Huzhou, Huzhou, China

Minyan Xing

Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Haining, Zhejiang, China

Xiaoxi Chen

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Jiaohui Pang

Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China

Lingjun Zhu

Department of Oncology, Sir Run Run Hospital Nanjing Medical University, Nanjing, Jiangsu, China