Nature Communications (Feb 2021)
20S proteasomes secreted by the malaria parasite promote its growth
- Elya Dekel,
- Dana Yaffe,
- Irit Rosenhek-Goldian,
- Gili Ben-Nissan,
- Yifat Ofir-Birin,
- Mattia I. Morandi,
- Tamar Ziv,
- Xavier Sisquella,
- Matthew A. Pimentel,
- Thomas Nebl,
- Eugene Kapp,
- Yael Ohana Daniel,
- Paula Abou Karam,
- Daniel Alfandari,
- Ron Rotkopf,
- Shimrit Malihi,
- Tal Block Temin,
- Debakshi Mullick,
- Or-Yam Revach,
- Ariel Rudik,
- Nir S. Gov,
- Ido Azuri,
- Ziv Porat,
- Giulia Bergamaschi,
- Raya Sorkin,
- Gijs J. L. Wuite,
- Ori Avinoam,
- Teresa G. Carvalho,
- Sidney R. Cohen,
- Michal Sharon,
- Neta Regev-Rudzki
Affiliations
- Elya Dekel
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Dana Yaffe
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Irit Rosenhek-Goldian
- Department of Chemical Research Support, Weizmann Institute of Science
- Gili Ben-Nissan
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Yifat Ofir-Birin
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Mattia I. Morandi
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Tamar Ziv
- Smoler Proteomics Center, Department of Biology, Technion - Israel Institute of Technology
- Xavier Sisquella
- The Walter and Eliza Hall Institute of Medical Research
- Matthew A. Pimentel
- The Walter and Eliza Hall Institute of Medical Research
- Thomas Nebl
- The Walter and Eliza Hall Institute of Medical Research
- Eugene Kapp
- The Walter and Eliza Hall Institute of Medical Research
- Yael Ohana Daniel
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Paula Abou Karam
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Daniel Alfandari
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Ron Rotkopf
- Bioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science
- Shimrit Malihi
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Tal Block Temin
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Debakshi Mullick
- Bioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science
- Or-Yam Revach
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Ariel Rudik
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Nir S. Gov
- Department of Chemical and Biological Physics, Weizmann Institute of Science
- Ido Azuri
- Bioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science
- Ziv Porat
- Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science
- Giulia Bergamaschi
- Department of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam
- Raya Sorkin
- School of Chemistry, Tel Aviv University
- Gijs J. L. Wuite
- Department of Physics and Astronomy and LaserLab, Vrije Universiteit Amsterdam
- Ori Avinoam
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Teresa G. Carvalho
- Department of Physiology, Anatomy and Microbiology, La Trobe University
- Sidney R. Cohen
- Department of Chemical Research Support, Weizmann Institute of Science
- Michal Sharon
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Neta Regev-Rudzki
- Department of Biomolecular Sciences, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-021-21344-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs, priming the RBCs for parasite invasion.
