Nature Communications (Feb 2021)

20S proteasomes secreted by the malaria parasite promote its growth

  • Elya Dekel,
  • Dana Yaffe,
  • Irit Rosenhek-Goldian,
  • Gili Ben-Nissan,
  • Yifat Ofir-Birin,
  • Mattia I. Morandi,
  • Tamar Ziv,
  • Xavier Sisquella,
  • Matthew A. Pimentel,
  • Thomas Nebl,
  • Eugene Kapp,
  • Yael Ohana Daniel,
  • Paula Abou Karam,
  • Daniel Alfandari,
  • Ron Rotkopf,
  • Shimrit Malihi,
  • Tal Block Temin,
  • Debakshi Mullick,
  • Or-Yam Revach,
  • Ariel Rudik,
  • Nir S. Gov,
  • Ido Azuri,
  • Ziv Porat,
  • Giulia Bergamaschi,
  • Raya Sorkin,
  • Gijs J. L. Wuite,
  • Ori Avinoam,
  • Teresa G. Carvalho,
  • Sidney R. Cohen,
  • Michal Sharon,
  • Neta Regev-Rudzki

DOI
https://doi.org/10.1038/s41467-021-21344-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs, priming the RBCs for parasite invasion.