A <i>C. elegans</i> genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle function

Abstract

AbstractAt the neuromuscular junction (NMJ), postsynaptic ionotropic acetylcholine receptors (AChRs) transduce a chemical signal released from a cholinergic motor neuron into an electrical signal to induce muscle contraction. To identify regulators of postsynaptic function, we conducted a genome-wide RNAi screen for genes required for proper response to levamisole, a pharmacological agonist of ionotropic L-AChRs at the Caenorhabditis elegansepn-1Agas-1