A novel acquired EGFR-SEPT14 fusion confers differential drug resistance to EGFR inhibitors in lung adenocarcinoma

• Weidong Wang,
• Wang Lv,
• Hui Wang,
• Yang Xu,
• Junrong Yan,
• Han-Ming Shen,
• Liqun Shan,
• Jian Hu

Affiliations

Weidong Wang

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; Faculty of Health Sciences, University of Macau, Macau SAR 519000, China; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China

Wang Lv

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Hui Wang

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Yang Xu

Medical Department, Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu 210000, China

Junrong Yan

Medical Department, Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu 210000, China

Han-Ming Shen

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Faculty of Health Sciences, University of Macau, Macau SAR 519000, China

Liqun Shan

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; Department of Thoracic Surgery, The First People's Hospital of Wenling, Wenling, Zhejiang 317599, China; Corresponding author. Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Rd, Hangzhou, Zhejiang 310003, China. Fax: +86 571 87236847.

Jian Hu

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; Corresponding author. Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Rd, Hangzhou, Zhejiang 310003, China. Fax: +86 571 87236847.