Oral mucositis in children associated with hematopoietic stem cells transplant

Abstract

Oral mucositis is one of the most common complication of Hematopoietic stem cell transplant. It is extremely painful and affect the quality of life. 67%–99% of the patients develop oral mucositis and they are at a high risk of developing various infections. Several methods was introduced aiming to reduce the incidence and severity of oral mucositis. The objective of this review is to summarize the different modalities to reduces the incidence and severity of oral mucositis. The review includes human clinical trails with or without randomization, meta-analysis and systematic review. The review suggests that proper oral hygiene, mouth lubricant and the epidermal growth factor can help to reduce the severity of oral mucositis.

Keywords

• Hematopoietic stem cell transplant
• oral complication
• oral mucositis