Paroxysmal disorders in children receiving substitution therapy with vitamin B12

Abstract

Congenital deficiency of vitamin B12 in children is a frequent metabolic disorder in pediatric practice. The disease has multiple symptoms, including various somatic and nervous manifestations. The main symptom of vitamin B12 deficiency is the regression of psychomotor development with significant trophic impairments and changes in the internal organs. Without substitution therapy with vitamin B12, these children quickly develop irreversible disorders that can lead to death, whereas timely parenteral administration of vitamin B12 can ensure the restoration of the initial development level. We describe a patient aged 1 y. o. 4 months, who was diagnosed with vitamin B12 deficiency anemia and general vitamin B12 deficiency at the age of 8 months; as a result, the child developed various paroxysms that were considered to be epileptic. The patients started to receive vitamin B12 and antiepileptic drugs, which helped to achieve clinical remission with normal psychomotor development.

Keywords

• vitamin b12 deficiency
• substitution therapy with vitamin b12
• seizures in response to vitamin в12 injections