Nature Communications (Sep 2017)

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

  • Seweryn Mroczek,
  • Justyna Chlebowska,
  • Tomasz M. Kuliński,
  • Olga Gewartowska,
  • Jakub Gruchota,
  • Dominik Cysewski,
  • Vladyslava Liudkovska,
  • Ewa Borsuk,
  • Dominika Nowis,
  • Andrzej Dziembowski

DOI
https://doi.org/10.1038/s41467-017-00578-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 17

Abstract

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FAM46C is one of the most frequently mutated genes in multiple myeloma (MM), but its molecular function remains unknown. Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts.