A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

Moyan Wang; Xin Chen; Shuangyang Li; Lingxue Wang; Hongmei Tang; Yuting Pu; Dechou Zhang; Dechou Zhang; Bangjiang Fang; Bangjiang Fang; Xue Bai; Xue Bai

doi:10.3389/fncel.2024.1445919

Frontiers in Cellular Neuroscience (Nov 2024)

A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

Moyan Wang,
Xin Chen,
Shuangyang Li,
Lingxue Wang,
Hongmei Tang,
Yuting Pu,
Dechou Zhang,
Dechou Zhang,
Bangjiang Fang,
Bangjiang Fang,
Xue Bai,
Xue Bai

Affiliations

Moyan Wang: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Xin Chen: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Shuangyang Li: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Lingxue Wang: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Hongmei Tang: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Yuting Pu: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Dechou Zhang: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Dechou Zhang: Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, China
Bangjiang Fang: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Bangjiang Fang: Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Xue Bai: Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China
Xue Bai: Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, China

DOI: https://doi.org/10.3389/fncel.2024.1445919
Journal volume & issue: Vol. 18

Abstract

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Intracerebral hemorrhage (ICH) is a severe condition that devastatingly harms human health and poses a financial burden on families and society. Bcl-2 Associated X-protein (Bax) and B-cell lymphoma 2 (Bcl-2) are two classic apoptotic markers post-ICH. Beclin 1 offers a competitive architecture with that of Bax, both playing a vital role in autophagy. However, the interaction between Beclin 1 and Bcl-2/Bax has not been conjunctively analyzed. This review aims to examine the crosstalk between autophagy and apoptosis in ICH by focusing on the interaction and balance of Beclin 1, Bax, and Bcl-2. We also explored the therapeutic potential of Western conventional medicine and traditional Chinese medicine (TCM) in ICH via controlling the crosstalk between autophagy and apoptosis.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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Abstract

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