A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Xuexin Zhang; Trayambak Pathak; Ryan Yoast; Scott Emrich; Ping Xin; Robert M. Nwokonko; Martin Johnson; Shilan Wu; Céline Delierneux; Maxime Gueguinou; Nadine Hempel; James W. Putney; Donald L. Gill; Mohamed Trebak

doi:10.1038/s41467-019-09593-0

Nature Communications (Apr 2019)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Xuexin Zhang,
Trayambak Pathak,
Ryan Yoast,
Scott Emrich,
Ping Xin,
Robert M. Nwokonko,
Martin Johnson,
Shilan Wu,
Céline Delierneux,
Maxime Gueguinou,
Nadine Hempel,
James W. Putney,
Donald L. Gill,
Mohamed Trebak

Affiliations

Xuexin Zhang: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Trayambak Pathak: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Ryan Yoast: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Scott Emrich: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Ping Xin: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Robert M. Nwokonko: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Martin Johnson: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Shilan Wu: Department of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
Céline Delierneux: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Maxime Gueguinou: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Nadine Hempel: Department of Pharmacology, The Pennsylvania State University College of Medicine
James W. Putney: Department of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
Donald L. Gill: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine
Mohamed Trebak: Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine

DOI: https://doi.org/10.1038/s41467-019-09593-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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