Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops

• Steffen Heegaard,
• Anne Hedengran,
• Miriam Kolko,
• Darlene A Dartt,
• Goran Petrovski,
• Olivia Müllertz,
• Zaynab Ahmad Mouhammad,
• Josefine Freiberg,
• Richárd Nagymihály,
• Jette Jacobsen,
• Susan Weng Larsen,
• Jeffrey Bair,
• Tor Utheim

Affiliations

Steffen Heegaard

Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

Anne Hedengran

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

Miriam Kolko

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

Darlene A Dartt

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts, USA

Goran Petrovski

Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Olivia Müllertz

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

Zaynab Ahmad Mouhammad

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

Josefine Freiberg

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

Richárd Nagymihály

Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Jette Jacobsen

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark

Susan Weng Larsen

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark

Jeffrey Bair

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts, USA

Tor Utheim

Department of Medical Biochemistry, Oslo Universitetssykehus, Oslo, Norway