Nature Communications (Apr 2017)
Activin A more prominently regulates muscle mass in primates than does GDF8
- Esther Latres,
- Jason Mastaitis,
- Wen Fury,
- Lawrence Miloscio,
- Jesus Trejos,
- Jeffrey Pangilinan,
- Haruka Okamoto,
- Katie Cavino,
- Erqian Na,
- Angelos Papatheodorou,
- Tobias Willer,
- Yu Bai,
- Jee Hae Kim,
- Ashique Rafique,
- Stephen Jaspers,
- Trevor Stitt,
- Andrew J. Murphy,
- George D. Yancopoulos,
- Jesper Gromada
Affiliations
- Esther Latres
- Regeneron Pharmaceuticals, Inc.
- Jason Mastaitis
- Regeneron Pharmaceuticals, Inc.
- Wen Fury
- Regeneron Pharmaceuticals, Inc.
- Lawrence Miloscio
- Regeneron Pharmaceuticals, Inc.
- Jesus Trejos
- Regeneron Pharmaceuticals, Inc.
- Jeffrey Pangilinan
- Regeneron Pharmaceuticals, Inc.
- Haruka Okamoto
- Regeneron Pharmaceuticals, Inc.
- Katie Cavino
- Regeneron Pharmaceuticals, Inc.
- Erqian Na
- Regeneron Pharmaceuticals, Inc.
- Angelos Papatheodorou
- Regeneron Pharmaceuticals, Inc.
- Tobias Willer
- Regeneron Pharmaceuticals, Inc.
- Yu Bai
- Regeneron Pharmaceuticals, Inc.
- Jee Hae Kim
- Regeneron Pharmaceuticals, Inc.
- Ashique Rafique
- Regeneron Pharmaceuticals, Inc.
- Stephen Jaspers
- Regeneron Pharmaceuticals, Inc.
- Trevor Stitt
- Regeneron Pharmaceuticals, Inc.
- Andrew J. Murphy
- Regeneron Pharmaceuticals, Inc.
- George D. Yancopoulos
- Regeneron Pharmaceuticals, Inc.
- Jesper Gromada
- Regeneron Pharmaceuticals, Inc.
- DOI
- https://doi.org/10.1038/ncomms15153
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.
