RHOA and mDia1 promotes apoptosis of breast cancer cells via a high dose of doxorubicin treatment

Bober Peter; Alexovič Michal; Tomková Zuzana; Kilík Róbert; Sabo Ján

doi:10.1515/biol-2019-0070

Open Life Sciences (Dec 2019)

RHOA and mDia1 promotes apoptosis of breast cancer cells via a high dose of doxorubicin treatment

Bober Peter,
Alexovič Michal,
Tomková Zuzana,
Kilík Róbert,
Sabo Ján

Affiliations

Bober Peter: Department of Medical and Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, Trieda SNP1, 04011Košice, Slovakia
Alexovič Michal: Department of Medical and Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, Trieda SNP1, 04011Košice, Slovakia
Tomková Zuzana: Department of Medical and Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, Trieda SNP1, 04011Košice, Slovakia
Kilík Róbert: 1st Department of Surgery, Faculty of Medicine, University of P.J. Šafárik in Košice, Trieda SNP1, 04011Košice, Slovakia
Sabo Ján: Department of Medical and Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, Trieda SNP1, 04011Košice, Slovakia

DOI: https://doi.org/10.1515/biol-2019-0070
Journal volume & issue: Vol. 14, no. 1
pp. 619 – 627

Abstract

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Transforming RhoA proteins (RHOA) and their downstream Diaphanous homolog 1 proteins (DIAPH1) or mDia1 participate in the regulation of actin cytoskeleton which plays critical role in cells, i.e., morphologic changes and apoptosis.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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Abstract

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