Nature Communications (Jul 2019)
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
- Christina Vrahnas,
- Martha Blank,
- Toby A. Dite,
- Liliana Tatarczuch,
- Niloufar Ansari,
- Blessing Crimeen-Irwin,
- Huynh Nguyen,
- Mark R. Forwood,
- Yifang Hu,
- Mika Ikegame,
- Keith R. Bambery,
- Cyril Petibois,
- Eleanor J. Mackie,
- Mark J. Tobin,
- Gordon K. Smyth,
- Jonathan S. Oakhill,
- T. John Martin,
- Natalie A. Sims
Affiliations
- Christina Vrahnas
- Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research
- Martha Blank
- Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research
- Toby A. Dite
- Department of Medicine, The University of Melbourne, St. Vincent’s Hospital
- Liliana Tatarczuch
- Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne
- Niloufar Ansari
- Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research
- Blessing Crimeen-Irwin
- Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research
- Huynh Nguyen
- School of Medical Science and Menzies Health Institute Queensland, Griffith University
- Mark R. Forwood
- School of Medical Science and Menzies Health Institute Queensland, Griffith University
- Yifang Hu
- Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
- Mika Ikegame
- Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
- Keith R. Bambery
- Infrared Microspectroscopy (IRM) Beamline, ANSTO Australian Synchrotron
- Cyril Petibois
- University of Bordeaux, Inserm U1029 LAMC, Allée Geoffroy Saint-Hilaire Bat. B2
- Eleanor J. Mackie
- Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne
- Mark J. Tobin
- Infrared Microspectroscopy (IRM) Beamline, ANSTO Australian Synchrotron
- Gordon K. Smyth
- Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
- Jonathan S. Oakhill
- Department of Medicine, The University of Melbourne, St. Vincent’s Hospital
- T. John Martin
- Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research
- Natalie A. Sims
- Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-019-11373-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Osteoblasts mediate bone formation, and their differentiation requires expression of EphrinB2. Here, the authors show that EphrinB2 is also expressed by osteocytes, and that its genetic ablation in mice is associated with altered autophagy, elevated mineralization and brittle bone.
