Clinical, Cosmetic and Investigational Dermatology (Apr 2023)
Assessing the Rejuvenation Effectiveness of a Hyaluronic Acid and Amino Acid Mixture in the Periorbital Region
Abstract
Ayse Gul Kabakci,1,* Dursun Murat Bozkır,2,* Çağlar Cengizler,3,* Dilek Sire Eren,4,* Memduha Gülhal Bozkır1,* 1Department of Anatomy, Faculty of Medicine, Cukurova University, Adana, Turkey; 2Adana Sevgi Eye Center, Adana, Turkey; 3Biomedical Device Technology Program, Vocational School of Health Services, Izmir Democracy University, Izmir, Turkey; 4Dr Dilek Eren Medical Aesthetic Clinic, Adana, Turkey*These authors contributed equally to this workCorrespondence: Ayse Gul Kabakci, Cukurova University, Faculty of Medicine, Department of Anatomy, Sarıçam, Adana, 01250, Turkey, Tel +90 322 338 60 60-3489, Fax +90 322 338 65 72, Email [email protected]: We performed an assessment of the rejuvenation effect of an amino acid and hyaluronic acid mixture in the periorbital area.Methods: A total of 23 of the 35 participants completed all application sessions and measurements. These 23 women were aged 30– 55 years. A hyaluronic acid and amino acid mixture was injected into the participants’ periorbital area. Three sessions of application with 15-day intervals were undertaken. Subjects’ age, height, weight, smoking status, and sport participation were recorded. A photonumeric dark circle scale and Fitzpatrick’s periorbital wrinkling classification were used for evaluation of dark circles and wrinkles in the periorbital area. Anatomical measurements (height of upper and lower eyelids) were done using ImageJ and a skin-analysis system (Observ 520).Results: The 23 women had a mean age of 42.46± 9.33 years, mean height 164.46± 4.96 cm, and mean weight 63.94± 8.26 kg. Before the sessions, the mean heights of the upper eyelids were 1.24± 013 cm (right) and 1.21± 013 cm (left), while those of the lower eyelids were 0.98± 014 cm (right) and 0.97± 0.17 cm (left). One month after the third session, mean upper-eyelid heights were 1.30± 0.09 cm (right) and 1.28± 0.11 cm (left) and lower-eyelid ones 1.02± 0.11 cm (right) and 1.02± 0.13 cm (left). Dark-circle and wrinkle-scale scores showed significantly positive results between before the sessions and 1 month after the third session.Conclusion: A hyaluronic acid and amino acid mixture can be used to rejuvenation of the periorbital area in women aged 30– 55 years.Keywords: dark circle, periorbital anatomy, periorbital area, rejuvenation, wrinkle
