Scientific Reports (Aug 2021)

Impact of conduction disturbances on left ventricular mass regression and geometry change following transcatheter aortic valve replacement

  • Tsung-Yu Ko,
  • Hsien-Li Kao,
  • Ying-Ju Liu,
  • Chih-Fan Yeh,
  • Ching-Chang Huang,
  • Ying-Hsien Chen,
  • Chi-Sheng Hung,
  • Chih-Yang Chan,
  • Lung-Chun Lin,
  • Yih-Sharng Chen,
  • Mao-Shin Lin

DOI
https://doi.org/10.1038/s41598-021-96297-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Abstract Our study aimed to compare the difference of LV mass regression and remodeling in regard of conduction disturbances (CD) following transcatheter aortic valve replacement (TAVR). A prospective analysis of 152 consecutive TAVR patients was performed. 53 patients (34.9%) had CD following TAVR, including 30 (19.7%) permanent pacemaker implantation and 23 (15.2%) new left bundle branch block. In 123 patients with 1-year follow-up, significant improvement of LV ejection fraction (LVEF) (baseline vs 12-month: 65.1 ± 13.2 vs 68.7 ± 9.1, P = 0.017) and reduced LV end-systolic volume (LVESV) (39.8 ± 25.8 vs 34.3 ± 17.1, P = 0.011) was found in non-CD group (N = 85), but not in CD group (N = 38). Both groups had significant decrease in LV mass index (baseline vs 12-month: 148.6 ± 36.9 vs. 136.4 ± 34.7 in CD group, p = 0.023; 153.0 ± 50.5 vs. 125.6 ± 35.1 in non-CD group, p < 0.0001). In 46 patients with 3-year follow-up, only non-CD patients (N = 28) had statistically significant decrease in LV mass index (Baseline vs 36-month: 180.8 ± 58.8 vs 129.8 ± 39.1, p = 0.0001). Our study showed the improvement of LV systolic function, reduced LVESV and LV mass regression at 1 year could be observed in patients without CD after TAVR. Sustained LV mass regression within 3-year was found only in patients without CD.