BMC Infectious Diseases (Jun 2007)

The association of <it>RANTES </it>polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

  • Lim Wilina,
  • Chan Eric YT,
  • Au Ka,
  • Chow Eudora Y,
  • Yung Raymond WH,
  • Zhai Yun,
  • Fok Susanna,
  • Wong Wilfred,
  • Zhang Hongxing,
  • Law Helen,
  • Lee Loretta,
  • Chong Wai,
  • Zhou Gangqiao,
  • Ng Man,
  • Peiris JS Malik,
  • He Fuchu,
  • Lau Yu

DOI
https://doi.org/10.1186/1471-2334-7-50
Journal volume & issue
Vol. 7, no. 1
p. 50

Abstract

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Abstract Background Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls. Results RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32–4.64) and 3.06-fold (95%CI:1.47–6.39) increased risk of developing SARS respectively (P P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11–4.06) and 4.01-fold (95% CI: 1.30–12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64–11.1) and GG (OR = 3.34, 95%CI:0.37–30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011). Conclusion RANTES -28 G allele plays a role in the pathogenesis of SARS.