Mathematical Modeling of the Tumor–Immune System with Time Delay and Diffusion

Abstract

This paper proposes a partial differential equation model based on the model introduced by V. A. Kuznetsov and M. A. Taylor, which explains the dynamics of a tumor–immune interaction system, where the immune reactions are described by a Michaelis–Menten function. In this work, time delay and diffusion process are considered in order to make the studied model closer to reality. Firstly, we analyze the local stability of equilibria and the existence of Hopf bifurcation by using the delay as a bifurcation parameter. Secondly, we use the normal form theory and the center manifold reduction to determine the normal form of Hopf bifurcation for the studied model. Finally, some numerical simulations are provided to illustrate the analytic results. We show how diffusion has a significant effect on the dynamics of the delayed interaction tumor–immune system.

Keywords

• differential equations
• Hopf bifurcation
• diffusion
• time-delay