A glutamine sensor that directly activates TORC1

Mirai Tanigawa; Katsuyoshi Yamamoto; Satoru Nagatoishi; Koji Nagata; Daisuke Noshiro; Nobuo N. Noda; Kouhei Tsumoto; Tatsuya Maeda

doi:10.1038/s42003-021-02625-w

Communications Biology (Sep 2021)

A glutamine sensor that directly activates TORC1

Mirai Tanigawa,
Katsuyoshi Yamamoto,
Satoru Nagatoishi,
Koji Nagata,
Daisuke Noshiro,
Nobuo N. Noda,
Kouhei Tsumoto,
Tatsuya Maeda

Affiliations

Mirai Tanigawa: Departments of Biology, Hamamatsu University School of Medicine
Katsuyoshi Yamamoto: Institute for Quantitative Biosciences, The University of Tokyo
Satoru Nagatoishi: The Institute of Medical Science, The University of Tokyo
Koji Nagata: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Daisuke Noshiro: Institute of Microbial Chemistry (BIKAKEN)
Nobuo N. Noda: Institute of Microbial Chemistry (BIKAKEN)
Kouhei Tsumoto: The Institute of Medical Science, The University of Tokyo
Tatsuya Maeda: Departments of Biology, Hamamatsu University School of Medicine

DOI: https://doi.org/10.1038/s42003-021-02625-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Tanigawa et al. investigate the role of Pib2, a vacuolar protein, in the glutamine-dependent upstream regulation of TORC1 in budding yeast. Their study reveals that Pib2 plays dual roles as a glutamine sensor and a direct TORC1 activator, a finding useful for the community working on TORC1 upstream regulation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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