Mìžnarodnij Endokrinologìčnij Žurnal (May 2018)
The role of adipocytokines in the development of non-alcoholic fatty liver disease in patients with hypertension and obesity
Abstract
Background. Incidence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world along with epidemic of obesity (OB) and type 2 diabetes mellitus. The purpose of the study was to analyze the levels of leptin, adiponectin and leptin resistance in patients with NAFLD and OB. Materials and methods. The study involved 96 patients with NAFLD. The average age of patients was 53.70 ± 5.34 years. Compensated type 2 diabetes mellitus was diagnosed in 44 individuals. Fifty apparently healthy people matched by age and sex (60 % — women, 40 % — men) were included into the control group. Levels of leptin, adiponectin were studied by enzyme-linked immunosorbent assay. Results. It was found that leptin levels are much higher (1.74–2.39 times; p < 0.001) in women than in men, regardless of the type of NAFLD (steatosis or non-alcoholic steatohepatitis (NASH)) and the degrees of OB. In men with steatohepatosis, the concentration of leptin prevailed over that of men with steatohepatitis — by 25.39 % (pNASH < 0.05). Additionally, in the presence of OB degree III, the content of leptin was higher than in OB degrees I and II, regardless of sex. There was an increase in the rate of leptin resistance by 22.22 % (p < 0.05) in steatosis, and by 46.15 % (p = 0.035) and 42.79 % (p = 0.044), respectively, in patients with NAFLD in general and with OB degree III. On the contrary, the concentration of anti-inflammatory adiponectin in OB degrees II and III was lower than in OB degree I by 5.73 and 5.91 % (p < 0.05). Conclusions. The course of NAFLD is accompanied by disorders in the secretory function of adipose tissue, hyperleptinemia, more severe in women, without a clear dependence of steatosis or NASH and the degree of obesity. OB degrees II and III is associated with lower content of adiponectin (p < 0.05).
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