A positive feedback loop bi-stably activates fibroblasts

So-Young Yeo; Keun-Woo Lee; Dongkwan Shin; Sugyun An; Kwang-Hyun Cho; Seok-Hyung Kim

doi:10.1038/s41467-018-05274-6

Nature Communications (Aug 2018)

A positive feedback loop bi-stably activates fibroblasts

So-Young Yeo,
Keun-Woo Lee,
Dongkwan Shin,
Sugyun An,
Kwang-Hyun Cho,
Seok-Hyung Kim

Affiliations

So-Young Yeo: Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University
Keun-Woo Lee: Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University
Dongkwan Shin: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Sugyun An: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Kwang-Hyun Cho: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Seok-Hyung Kim: Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University

DOI: https://doi.org/10.1038/s41467-018-05274-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

Read online

Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C bi-stably.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal