The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria

mBio (Apr 2021)

Affiliations

Allison Fay: Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
John Philip: Microchemistry and Proteomics Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Priya Saha: Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA
Ronald C. Hendrickson: Microchemistry and Proteomics Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Michael S. Glickman: ORCiD; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Kristin Burns-Huang: ORCiD; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA

Abstract

AMR is a global problem, especially for TB. Here, we show that mycobacterial chaperones support AMR in M. smegmatisM. tuberculosis