mSphere
(Apr 2021)
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Christopher Fröhlich,
João A. Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte A. Lund,
Marc W. van der Kamp,
Pål J. Johnsen,
Ørjan Samuelsen,
Hanna-Kirsti S. Leiros
Affiliations
Christopher Fröhlich
ORCiD The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway
João A. Gama
ORCiD Department of Pharmacy, UiT The Arctic University of Norway, Tromsø, Norway
Klaus Harms
ORCiD Department of Pharmacy, UiT The Arctic University of Norway, Tromsø, Norway
Viivi H. A. Hirvonen
ORCiD School of Biochemistry, University of Bristol, Bristol, United Kingdom
Bjarte A. Lund
ORCiD Hylleraas Centre for Quantum Molecular Sciences, Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway
Marc W. van der Kamp
ORCiD School of Biochemistry, University of Bristol, Bristol, United Kingdom
Pål J. Johnsen
ORCiD Department of Pharmacy, UiT The Arctic University of Norway, Tromsø, Norway
Ørjan Samuelsen
ORCiD Department of Pharmacy, UiT The Arctic University of Norway, Tromsø, Norway
Hanna-Kirsti S. Leiros
ORCiD The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway
DOI
https://doi.org/10.1128/mSphere.00108-21
Journal volume & issue
Vol. 6,
no. 2
Abstract
Read online
Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicrobial classes, the importance of β-lactams, the most commonly used antibiotics, is still poorly studied.
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