Predictors of NAFLD rapidly progression in type 2 diabetes patients

Abstract

The goal of our case-control research was to study the associations between speed progression of NAFLD and risk factors among patients with the type 2 diabetes. 82 patients with type 2 diabetes and NAFLD took part in the study. We divided the patients into two groups: with speed (n=38) and slow (n=44) progression of fibrosis. The results of our study revealed the definitive associations between speedy progression of fibrosis and the level of insulin, ACT and alkaline phosphatase. We found the direct relations of speed fibrosis progression with the level of TC and TG. We also showed the significant influence the inflammatory mechanisms have on fibrosis progression (direct definitive relations between fibrosis and the consistence of cytokines - IL-1β (OR 1,017; р=0,035), TNF-α (OR 0,004; р=0,049) and the inverse relations between the speed progression of fibrosis and the consistence of IL-6 (OR 0,94; р=0,058). Using the results of a step-by-step multivariate regression analysis we created the final clinical model of fibrosis speed progression among the type two diabetes patients and people affected with NAFLD, which includes six prognostic variables: TG, alkaline phosphatase, insulin, IL-6, TNF-α and adiponectin.

Keywords

• diabetes mellitus type two
• nonalcoholic fatty liver disease
• fibrosis