Nature Communications (Jul 2021)
Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
- Mi-Ok Lee,
- Su-gi Lee,
- Cho-Rok Jung,
- Ye Seul Son,
- Jae-Woon Ryu,
- Kwang Bo Jung,
- Jun-Ho Ahn,
- Jung-Hwa Oh,
- Hyang-Ae Lee,
- Jung Hwa Lim,
- Janghwan Kim,
- Insu Jang,
- Jinhyuk Choi,
- Jaeeun Jung,
- Kunhyang Park,
- Byungwook Lee,
- Dae-Soo Kim,
- Mi-Young Son,
- Hyun-Soo Cho
Affiliations
- Mi-Ok Lee
- Korea Research Institute of Bioscience and Biotechnology
- Su-gi Lee
- Korea Research Institute of Bioscience and Biotechnology
- Cho-Rok Jung
- Korea Research Institute of Bioscience and Biotechnology
- Ye Seul Son
- Korea Research Institute of Bioscience and Biotechnology
- Jae-Woon Ryu
- Korea Research Institute of Bioscience and Biotechnology
- Kwang Bo Jung
- Korea Research Institute of Bioscience and Biotechnology
- Jun-Ho Ahn
- Korea Institute of Toxicology (KIT)
- Jung-Hwa Oh
- Korea Institute of Toxicology (KIT)
- Hyang-Ae Lee
- Korea Institute of Toxicology (KIT)
- Jung Hwa Lim
- Korea Research Institute of Bioscience and Biotechnology
- Janghwan Kim
- Korea Research Institute of Bioscience and Biotechnology
- Insu Jang
- Korea Research Institute of Bioscience and Biotechnology
- Jinhyuk Choi
- Korea Research Institute of Bioscience and Biotechnology
- Jaeeun Jung
- Korea Research Institute of Bioscience and Biotechnology
- Kunhyang Park
- Korea Research Institute of Bioscience and Biotechnology
- Byungwook Lee
- Korea Research Institute of Bioscience and Biotechnology
- Dae-Soo Kim
- Korea Research Institute of Bioscience and Biotechnology
- Mi-Young Son
- Korea Research Institute of Bioscience and Biotechnology
- Hyun-Soo Cho
- Korea Research Institute of Bioscience and Biotechnology
- DOI
- https://doi.org/10.1038/s41467-021-24746-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs and perform validation on lung bud organoids, antral gastric organoids, and cardiomyocytes.
