Nature Communications (Dec 2021)
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing
- Cornelius H. L. Kürten,
- Aditi Kulkarni,
- Anthony R. Cillo,
- Patricia M. Santos,
- Anna K. Roble,
- Sayali Onkar,
- Carly Reeder,
- Stephan Lang,
- Xueer Chen,
- Umamaheswar Duvvuri,
- Seungwon Kim,
- Angen Liu,
- Tracy Tabib,
- Robert Lafyatis,
- Jian Feng,
- Shou-Jiang Gao,
- Tullia C. Bruno,
- Dario A. A. Vignali,
- Xinghua Lu,
- Riyue Bao,
- Lazar Vujanovic,
- Robert L. Ferris
Affiliations
- Cornelius H. L. Kürten
- Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen
- Aditi Kulkarni
- UPMC Hillman Cancer Center, University of Pittsburgh
- Anthony R. Cillo
- UPMC Hillman Cancer Center, University of Pittsburgh
- Patricia M. Santos
- UPMC Hillman Cancer Center, University of Pittsburgh
- Anna K. Roble
- UPMC Hillman Cancer Center, University of Pittsburgh
- Sayali Onkar
- UPMC Hillman Cancer Center, University of Pittsburgh
- Carly Reeder
- UPMC Hillman Cancer Center, University of Pittsburgh
- Stephan Lang
- Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen
- Xueer Chen
- Deparment of Biomedical Informatics, University of Pittsburgh
- Umamaheswar Duvvuri
- Department of Otolaryngology, University of Pittsburgh
- Seungwon Kim
- Department of Otolaryngology, University of Pittsburgh
- Angen Liu
- Department of Otolaryngology, University of Pittsburgh
- Tracy Tabib
- Division of Rheumatology and Clinical Immunology, University of Pittsburgh
- Robert Lafyatis
- Division of Rheumatology and Clinical Immunology, University of Pittsburgh
- Jian Feng
- UPMC Hillman Cancer Center, University of Pittsburgh
- Shou-Jiang Gao
- UPMC Hillman Cancer Center, University of Pittsburgh
- Tullia C. Bruno
- UPMC Hillman Cancer Center, University of Pittsburgh
- Dario A. A. Vignali
- UPMC Hillman Cancer Center, University of Pittsburgh
- Xinghua Lu
- Deparment of Biomedical Informatics, University of Pittsburgh
- Riyue Bao
- UPMC Hillman Cancer Center, University of Pittsburgh
- Lazar Vujanovic
- UPMC Hillman Cancer Center, University of Pittsburgh
- Robert L. Ferris
- UPMC Hillman Cancer Center, University of Pittsburgh
- DOI
- https://doi.org/10.1038/s41467-021-27619-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
The tumor microenvironment (TME) has an important role in Head and Neck Squamous Cell Carcinoma (HNSCC) progression. Here, using single-cell RNA sequencing and multiplexed imaging, the authors report the cellular complexity of the TME in patients with HNSCC, exploring inflammatory status, stromal heterogeneity and immune checkpoint receptor-ligand interactions.
