Does V1 response suppression initiate binocular rivalry?

Brock M. Carlson; Blake A. Mitchell; Kacie Dougherty; Jacob A. Westerberg; Michele A. Cox; Alexander Maier

iScience (Aug 2023)

Does V1 response suppression initiate binocular rivalry?

Brock M. Carlson,
Blake A. Mitchell,
Kacie Dougherty,
Jacob A. Westerberg,
Michele A. Cox,
Alexander Maier

Affiliations

Brock M. Carlson: Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA
Blake A. Mitchell: Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA
Kacie Dougherty: Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA; Department of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA
Jacob A. Westerberg: Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA; Department of Vision and Cognition, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam 1105 BA, the Netherlands
Michele A. Cox: Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA; Center for Visual Science, University of Rochester, Rochester, NY 14627, USA
Alexander Maier: Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA; Corresponding author

Journal volume & issue: Vol. 26, no. 8
p. 107359

Abstract

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Summary: During binocular rivalry (BR) only one eye’s view is perceived. Neural underpinnings of BR are debated. Recent studies suggest that primary visual cortex (V1) initiates BR. One trigger might be response suppression across most V1 neurons at the onset of BR. Here, we utilize a variant of BR called binocular rivalry flash suppression (BRFS) to test this hypothesis. BRFS is identical to BR, except stimuli are shown with a ∼1s delay. If V1 response suppression was required to initiate BR, it should occur during BRFS as well. To test this, we compared V1 spiking in two macaques observing BRFS. We found that BRFS resulted in response facilitation rather than response suppression across V1 neurons. However, BRFS still reduces responses in a subset of V1 neurons due to the adaptive effects of asynchronous stimulus presentation. We argue that this selective response suppression could serve as an alternate initiator of BR.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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