Nature Communications (May 2019)

Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro

  • Alona Feldman,
  • Dzmitry Mukha,
  • Itzhak I. Maor,
  • Egor Sedov,
  • Elle Koren,
  • Yahav Yosefzon,
  • Tomer Shlomi,
  • Yaron Fuchs

DOI
https://doi.org/10.1038/s41467-019-10261-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The sebaceous gland (SG) has been proposed to be replenished by pools of cells, including a population in the SG base, marked by Blimp1. Here, the authors show that Blimp1+ cells can establish an organoid model of the SG, which is regulated by c-Myc and can recapitulate the early stages of acne vulgaris.