Nature Communications (Mar 2023)
Decrypting the programming of β-methylation in virginiamycin M biosynthesis
Abstract
Biosynthesis of complex polyketides by polyketide synthases often relies on trans-acting enzymes to modify the intermediates. Here, the authors elucidate how β-methylation enzymes identify their substrates. The recognition is imperfect, resulting in a doubly β-methylated virginiamycin derivative.