Nature Communications (Jan 2018)
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
- TingDong Yan,
- Wen Fong Ooi,
- Aditi Qamra,
- Alice Cheung,
- DongLiang Ma,
- Gopinath Meenakshi Sundaram,
- Chang Xu,
- Manjie Xing,
- LaiFong Poon,
- Jing Wang,
- Yan Ping Loh,
- Jess Hui Jie Ho,
- Joscelyn Jun Quan Ng,
- Muhammad Khairul Ramlee,
- Luay Aswad,
- Steve G. Rozen,
- Sujoy Ghosh,
- Frederic A. Bard,
- Prabha Sampath,
- Vinay Tergaonkar,
- James O. J. Davies,
- Jim R. Hughes,
- Eyleen Goh,
- Xuezhi Bi,
- Melissa Jane Fullwood,
- Patrick Tan,
- Shang Li
Affiliations
- TingDong Yan
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Wen Fong Ooi
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Aditi Qamra
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Alice Cheung
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- DongLiang Ma
- Neuroscience Academic Clinical Programme, Duke-NUS Medical School
- Gopinath Meenakshi Sundaram
- Institute of Medical Biology (IMB)
- Chang Xu
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Manjie Xing
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- LaiFong Poon
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Jing Wang
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Yan Ping Loh
- Cancer Science Institute of Singapore, National University of Singapore
- Jess Hui Jie Ho
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Joscelyn Jun Quan Ng
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Muhammad Khairul Ramlee
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Luay Aswad
- Cancer Science Institute of Singapore, National University of Singapore
- Steve G. Rozen
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Sujoy Ghosh
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School
- Frederic A. Bard
- Institute of Molecular and Cell Biology (IMCB)
- Prabha Sampath
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Vinay Tergaonkar
- Institute of Molecular and Cell Biology (IMCB)
- James O. J. Davies
- Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University
- Jim R. Hughes
- Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University
- Eyleen Goh
- Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
- Xuezhi Bi
- Bioprocessing Technology Institute
- Melissa Jane Fullwood
- Cancer Science Institute of Singapore, National University of Singapore
- Patrick Tan
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Shang Li
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- DOI
- https://doi.org/10.1038/s41467-017-02601-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic elements of hTERT.
