Synthesis of fatty acyl CoA and other thiol esters using N-hydroxysuccinimide esters of fatty acids

Abstract

N-Hydroxysuccinimide esters of long-chain fatty acids have been used to synthesize the CoA and thioglycolic acid thiol esters of palmitic and 3-ketopalmitic acids in high yield and with a minimum of untoward side reactions.

Keywords

• palmitoyl-S-CoA
• 3-ketopalmitoyl-S-thioglycolate
• ketal of 3-ketopalmitic acid