Assessment of the Relationship between Expression of p63 with Different Clinical Types of Oral Lichen Planus: A Retrospective Immunohistochemistry Study

Abstract

Introduction: We aimed to assess the expression of p63 among different clinical types of oral lichen planus. Methods: The current study includes 44 oral lichen planus cases from the oral pathology laboratory, oral diagnostic department, Baghdad University. P63-PRM114P used as primary monoclonal antibodies. The intensity of immunohistochemistry activity was calculated utilizing the following criteria: weak intensity: one positive cell, moderate intensity: two positive cells, and strong intensity: three or more positive cells (magnification 20×). Results: The mean age of participants was 52.82 ± 12. No significant relationship found between gender and expression of p63 (P = 0.65). The p63 expressed in all clinical types of oral lichen planus (OLP). Yet, expression of p63 was not significantly related to the clinical type of OLP (P = 0.98). Conclusion: We could not found relationship between expression of p63 among different clinical types of oral lichen planus. With respect to the limited sample size of this study, some larger scale studies among different populations are need to reach to a definitive conclusion regarding relationship between expression of p63 among different clinical types of oral lichen planus.

Keywords

• biomarkers
• immunohistochemistry
• oral lichen planus
• p63