Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

Christopher D. Scharer; Dillon G. Patterson; Tian Mi; Madeline J. Price; Sakeenah L. Hicks; Jeremy M. Boss

doi:10.1038/s41467-020-17798-x

Nature Communications (Aug 2020)

Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

Christopher D. Scharer,
Dillon G. Patterson,
Tian Mi,
Madeline J. Price,
Sakeenah L. Hicks,
Jeremy M. Boss

Affiliations

Christopher D. Scharer: Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine
Dillon G. Patterson: Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine
Tian Mi: Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine
Madeline J. Price: Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine
Sakeenah L. Hicks: Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine
Jeremy M. Boss: Department of Microbiology and Immunology and the Emory Vaccine Center, Emory University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-17798-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell activation, and is coordinated by specific transcriptome programs and proliferation kinetics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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