Nature Communications (Feb 2022)
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice
- Francesco De Logu,
- Romina Nassini,
- Alan Hegron,
- Lorenzo Landini,
- Dane D. Jensen,
- Rocco Latorre,
- Julia Ding,
- Matilde Marini,
- Daniel Souza Monteiro de Araujo,
- Paulina Ramírez-Garcia,
- Michael Whittaker,
- Jeffri Retamal,
- Mustafa Titiz,
- Alessandro Innocenti,
- Thomas P. Davis,
- Nicholas Veldhuis,
- Brian L. Schmidt,
- Nigel W. Bunnett,
- Pierangelo Geppetti
Affiliations
- Francesco De Logu
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- Romina Nassini
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- Alan Hegron
- Department of Molecular Pathobiology, College of Dentistry, New York University
- Lorenzo Landini
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- Dane D. Jensen
- Department of Molecular Pathobiology, College of Dentistry, New York University
- Rocco Latorre
- Department of Molecular Pathobiology, College of Dentistry, New York University
- Julia Ding
- Department of Anesthesiology, Columbia University
- Matilde Marini
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- Daniel Souza Monteiro de Araujo
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- Paulina Ramírez-Garcia
- Drug Discovery Biology Theme and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
- Michael Whittaker
- Drug Discovery Biology Theme and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
- Jeffri Retamal
- Drug Discovery Biology Theme and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
- Mustafa Titiz
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- Alessandro Innocenti
- Plastic and Reconstructive Microsurgery - Careggi University Hospital
- Thomas P. Davis
- Drug Discovery Biology Theme and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
- Nicholas Veldhuis
- Drug Discovery Biology Theme and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
- Brian L. Schmidt
- Department of Molecular Pathobiology, College of Dentistry, New York University
- Nigel W. Bunnett
- Department of Molecular Pathobiology, College of Dentistry, New York University
- Pierangelo Geppetti
- Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence
- DOI
- https://doi.org/10.1038/s41467-022-28204-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
