Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats
Natalie de Almeida Barros,
Felipe J. Aidar,
Anderson Carlos Marçal,
Jymmys L. Santos,
Raphael Fabricio de Souza,
Jainara Lima Menezes,
Margarete Zanardo Gomes,
Dihogo Gama de Matos,
Eduardo Borba Neves,
André Luiz Gomes Carneiro,
Paulo Francisco de Almeida-Neto,
Breno Guilherme de Araújo Tinoco Cabral,
Reinaldo Viana Belo Neto,
Beat Knechtle,
Filipe Manuel Clemente,
Enilton Aparecido Camargo
Affiliations
Natalie de Almeida Barros
Graduate Program in Health Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Felipe J. Aidar
Graduate Program of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Anderson Carlos Marçal
Graduate Program of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Jymmys L. Santos
Graduate Program of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Raphael Fabricio de Souza
Graduate Program of Physical Education, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Jainara Lima Menezes
Graduate Program of Physiological Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Margarete Zanardo Gomes
Laboratory of Morphology and Experimental Pathology, University Tiradentes (UNIT), Aracaju 49010-390, Brazil
Dihogo Gama de Matos
Cardiovascular & Physiology of Exercise Laboratory, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Eduardo Borba Neves
Graduate Program on Biomedical Engineering, Federal Technological University of Paraná (PPGEB/UTFPR), Curitiba 80230-901, Brazil
André Luiz Gomes Carneiro
Department of Physical Education, State University of Montes Claros, Montes Claros 39401-089, Brazil
Paulo Francisco de Almeida-Neto
Department of Physical Education, Federal University of Rio Grande do Norte, Natal 59064-741, Brazil
Breno Guilherme de Araújo Tinoco Cabral
Department of Physical Education, Federal University of Rio Grande do Norte, Natal 59064-741, Brazil
Reinaldo Viana Belo Neto
Laboratory of Morphology and Experimental Pathology, University Tiradentes (UNIT), Aracaju 49010-390, Brazil
Beat Knechtle
Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
Filipe Manuel Clemente
Escola Superior Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun’Álvares, 4900-347 Viana do Castelo, Portugal
Enilton Aparecido Camargo
Graduate Program in Health Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Brazil
Background: Spinal cord injury (SCI) is a condition that affects the central nervous system, is characterized by motor and sensory impairments, and impacts individuals’ lives. The objective of this study was to evaluate the effects of resistance training on oxidative stress and muscle damage in spinal cord injured rats. Methodology: Forty Wistar rats were selected and divided equally into five groups: Healthy Control (CON), Sham (SHAM) SCI Untrained group (SCI-U), SCI Trained group (SCI- T), SCI Active Trained group (SCI- AT). Animals in the trained groups were submitted to an incomplete SCI at T9. Thereafter, they performed a protocol of resistance training for four weeks. Results: Significant differences in muscle damage markers and oxidative stress in the trained groups, mainly in SCI- AT, were found. On the other hand, SCI- U group presented higher levels of oxidative stress and biomarkers of LDH and AST. Conclusion: The results highlight that resistance training promoted a decrease in oxidative stress and a significative response in muscle damage markers.
