Composite Materials Based on Calcium Polyphosphate, PVA and Mg²⁺ for Bone Applications

Abstract

Polyphosphate (PP) is an inorganic polymer formed by the condensation of orthophosphate groups and represented by the formula [PO3−]n. Due to its properties, such as biocompatibility and low toxicity, polyphosphate presents itself as a biomimetic compound of hydroxyapatite, the main constituent of bone tissue. PP can be applied for bone tissue applications as a ceramic material in the form of calcium polyphosphate (CPP), due to its chemical similarity with hydroxyapatite. Thus, CPP has been used to develop scaffolds for bone tissue repair. However, CPP does not have adequate mechanical properties for application in bone, requiring the use of substances that add other properties to the material, such as resistance to compression and tension. For this, polymers, ions, and nanoparticles have been used as additives. In this context, this work presents the development of composite materials based on CPP, PVA, and Mg2+ as candidates for bone applications. The production of materials was based on the precipitation of CPP in an aqueous medium containing a pre-solubilized polymer, followed by the addition of Mg2+. The materials were characterized by TGA, SEM, EDS, and Raman. The results confirmed the formation of the composites, presenting a porous structure and containing a Ca/P ratio of 0.90. Thus, these composites have the potential to be applied in bone regeneration applications.

Keywords

• hydroxyapatite
• polymer
• biomaterials
• tissue repair