The results of the study of sensitivity to antibacterial drugs in isolates of Salmonella enterica isolated from poultry are shown in the article. Antibacterial sensitivity was determined by disc diffusion to such drugs: ampicillin, cefoperazone, ceftriaxone, ceftazidime, tetracycline, doxycycline, streptomycin, gentamicin, nalidixic acid, chloramphenicol, ciprofloxacin, trimethoprim. Growth retardation zones were interpreted according to the CLSI standard. Among the isolates tested, a significant percentage of isolates resistant to nalidixic acid and ciprofloxacin were found – (19 (63.3 %) and – 21 (70 %), respectively. A significant number of isolates were also resistant to beta-lactams. In particular, 37 isolates (64.9 %) were resistant to ceftazidime, and 36 (63.1 %) to ceftriaxone. However, ceftriaxone resistance was dominant among S. typhimurium isolates, whereas in Enteritidis this indicator was significantly lower. However, the highest resistance of the studied isolates were shown to the beta-lactam class – cefoperazone (70.17 %). Only 6 isolates (20 %) were sensitive to nalidixic acid but did not detect any isolates sensitive to ciprofloxacin. This is a significant problem because quinolones are used to treat invasive salmonellosis. In this study, 12 (40 %) isolates were sensitive to ampicillin, 9 (30 %) to cefoperazone, 10 (33.3 %) to ceftriaxone and 9 (30 %) to ceftazidime. The lowest number of strains was resistant to trimethoprim – 9 (30 %) and chloramphenicol – 8 (26.6 %). Unfortunately, the use of the latter is limited due to the possibility of serious side effects. Overall, the group of poultry isolates tested reflects a general upward trend in antibiotic resistance. The findings present new data on resistance and provide prospects for further studies on this aspect of salmonellosis.