Nature Communications (Jan 2019)
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
- Christopher E. Mahoney,
- David Pirman,
- Victor Chubukov,
- Taryn Sleger,
- Sebastian Hayes,
- Zi Peng Fan,
- Eric L. Allen,
- Ying Chen,
- Lingling Huang,
- Meina Liu,
- Yingjia Zhang,
- Gabrielle McDonald,
- Rohini Narayanaswamy,
- Sung Choe,
- Yue Chen,
- Stefan Gross,
- Giovanni Cianchetta,
- Anil K. Padyana,
- Stuart Murray,
- Wei Liu,
- Kevin M. Marks,
- Joshua Murtie,
- Marion Dorsch,
- Shengfang Jin,
- Nelamangala Nagaraja,
- Scott A. Biller,
- Thomas Roddy,
- Janeta Popovici-Muller,
- Gromoslaw A. Smolen
Affiliations
- Christopher E. Mahoney
- Agios Pharmaceuticals
- David Pirman
- Agios Pharmaceuticals
- Victor Chubukov
- Agios Pharmaceuticals
- Taryn Sleger
- Agios Pharmaceuticals
- Sebastian Hayes
- Agios Pharmaceuticals
- Zi Peng Fan
- Agios Pharmaceuticals
- Eric L. Allen
- Agios Pharmaceuticals
- Ying Chen
- Shanghai ChemPartner Co. Ltd.
- Lingling Huang
- Shanghai ChemPartner Co. Ltd.
- Meina Liu
- Shanghai ChemPartner Co. Ltd.
- Yingjia Zhang
- Shanghai ChemPartner Co. Ltd.
- Gabrielle McDonald
- Agios Pharmaceuticals
- Rohini Narayanaswamy
- Agios Pharmaceuticals
- Sung Choe
- Agios Pharmaceuticals
- Yue Chen
- Agios Pharmaceuticals
- Stefan Gross
- Agios Pharmaceuticals
- Giovanni Cianchetta
- Agios Pharmaceuticals
- Anil K. Padyana
- Agios Pharmaceuticals
- Stuart Murray
- Agios Pharmaceuticals
- Wei Liu
- Agios Pharmaceuticals
- Kevin M. Marks
- Agios Pharmaceuticals
- Joshua Murtie
- Agios Pharmaceuticals
- Marion Dorsch
- Agios Pharmaceuticals
- Shengfang Jin
- Agios Pharmaceuticals
- Nelamangala Nagaraja
- Agios Pharmaceuticals
- Scott A. Biller
- Agios Pharmaceuticals
- Thomas Roddy
- Agios Pharmaceuticals
- Janeta Popovici-Muller
- Agios Pharmaceuticals
- Gromoslaw A. Smolen
- Agios Pharmaceuticals
- DOI
- https://doi.org/10.1038/s41467-018-07959-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol biosynthetic pathway, due to the toxic accumulation of pathway intermediate squalene.
