Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor

Shuting Xu; Xinyuan Zhu; Chuan Zhang; Wei Huang; Yongfeng Zhou; Deyue Yan

doi:10.1038/s41467-018-04318-1

Nature Communications (May 2018)

Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor

Shuting Xu,
Xinyuan Zhu,
Chuan Zhang,
Wei Huang,
Yongfeng Zhou,
Deyue Yan

Affiliations

Shuting Xu: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University
Xinyuan Zhu: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University
Chuan Zhang: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University
Wei Huang: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University
Yongfeng Zhou: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University
Deyue Yan: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-018-04318-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Photodynamic therapy has attracted interest in treating cancer but it is limited in hypoxic tumors due to a lack of oxygen. Here, the authors describe a nano-composite capable of generating oxygen under near-infrared light for improved photodynamic and chemotherapy for treating cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal