Nature Communications (Oct 2017)
Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
- Cristina Llorente,
- Peter Jepsen,
- Tatsuo Inamine,
- Lirui Wang,
- Sena Bluemel,
- Hui J. Wang,
- Rohit Loomba,
- Jasmohan S. Bajaj,
- Mitchell L. Schubert,
- Masoumeh Sikaroodi,
- Patrick M. Gillevet,
- Jun Xu,
- Tatiana Kisseleva,
- Samuel B. Ho,
- Jessica DePew,
- Xin Du,
- Henrik T. Sørensen,
- Hendrik Vilstrup,
- Karen E. Nelson,
- David A. Brenner,
- Derrick E. Fouts,
- Bernd Schnabl
Affiliations
- Cristina Llorente
- Department of Medicine, University of California San Diego
- Peter Jepsen
- Department of Hepatology and Gastroenterology, Aarhus University Hospital
- Tatsuo Inamine
- Department of Medicine, University of California San Diego
- Lirui Wang
- Department of Medicine, University of California San Diego
- Sena Bluemel
- Department of Medicine, University of California San Diego
- Hui J. Wang
- Department of Medicine, University of California San Diego
- Rohit Loomba
- Department of Medicine, University of California San Diego
- Jasmohan S. Bajaj
- Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center
- Mitchell L. Schubert
- Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center
- Masoumeh Sikaroodi
- Microbiome Analysis Center, George Mason University
- Patrick M. Gillevet
- Microbiome Analysis Center, George Mason University
- Jun Xu
- Department of Surgery, University of California San Diego
- Tatiana Kisseleva
- Department of Surgery, University of California San Diego
- Samuel B. Ho
- Department of Medicine, University of California San Diego
- Jessica DePew
- J. Craig Venter Institute
- Xin Du
- Department of Medicine, University of California San Diego
- Henrik T. Sørensen
- Department of Clinical Epidemiology, Aarhus University Hospital
- Hendrik Vilstrup
- Department of Hepatology and Gastroenterology, Aarhus University Hospital
- Karen E. Nelson
- J. Craig Venter Institute
- David A. Brenner
- Department of Medicine, University of California San Diego
- Derrick E. Fouts
- J. Craig Venter Institute
- Bernd Schnabl
- Department of Medicine, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-017-00796-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.
