Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve

Chan Yang; Qinghua Liu; Yingjun Chen; Xiaodong Wang; Zaohong Ran; Fang Fang; Jiajun Xiong; Guoshi Liu; Xiang Li; Liguo Yang; Changjiu He

doi:10.1038/s42003-021-02042-z

Communications Biology (May 2021)

Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve

Chan Yang,
Qinghua Liu,
Yingjun Chen,
Xiaodong Wang,
Zaohong Ran,
Fang Fang,
Jiajun Xiong,
Guoshi Liu,
Xiang Li,
Liguo Yang,
Changjiu He

Affiliations

Chan Yang: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Qinghua Liu: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Yingjun Chen: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Xiaodong Wang: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Zaohong Ran: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Fang Fang: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Jiajun Xiong: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Guoshi Liu: College of Animal Science and Technology, China Agricultural University
Xiang Li: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Liguo Yang: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University
Changjiu He: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University

DOI: https://doi.org/10.1038/s42003-021-02042-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

Read online

Chan Yang, Qinghua Liu, et al. use in vitro and SNAT-null mouse models to investigate the role of melatonin in ovarian aging. Their results suggest that melatonin can delay ovarian aging by inhibiting follicle activation, growth and atresia, providing more insight into how melatonin impacts reproduction.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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