Nature Communications (May 2019)

Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility

  • Yi Luo,
  • Miriam Barrios-Rodiles,
  • Gagan D. Gupta,
  • Ying Y. Zhang,
  • Abiodun A. Ogunjimi,
  • Mikhail Bashkurov,
  • Johnny M. Tkach,
  • Ainsley Q. Underhill,
  • Liang Zhang,
  • Mohamed Bourmoum,
  • Jeffrey L. Wrana,
  • Laurence Pelletier

DOI
https://doi.org/10.1038/s41467-019-10241-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 20

Abstract

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Centrosomes function in cell migration by organizing microtubules. Here, Luo et al. surprisingly show that centrosome proteins also control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusive activity relevant to aggressive cancer motility.