Nature Communications (Feb 2017)
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
- Joonseok Cho,
- Yujian Zhang,
- Shi-Young Park,
- Anna-Maria Joseph,
- Chul Han,
- Hyo-Jin Park,
- Srilaxmi Kalavalapalli,
- Sung-Kook Chun,
- Drake Morgan,
- Jae-Sung Kim,
- Shinichi Someya,
- Clayton E. Mathews,
- Young Jae Lee,
- Stephanie E. Wohlgemuth,
- Nishanth E. Sunny,
- Hui-Young Lee,
- Cheol Soo Choi,
- Takayuki Shiratsuchi,
- S. Paul Oh,
- Naohiro Terada
Affiliations
- Joonseok Cho
- Department of Pathology, University of Florida College of Medicine
- Yujian Zhang
- Otsuka Maryland Medicinal Laboratories
- Shi-Young Park
- Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine
- Anna-Maria Joseph
- Department of Aging, University of Florida College of Medicine
- Chul Han
- Department of Aging, University of Florida College of Medicine
- Hyo-Jin Park
- Department of Aging, University of Florida College of Medicine
- Srilaxmi Kalavalapalli
- Department of Medicine, University of Florida College of Medicine
- Sung-Kook Chun
- Department of Surgery, University of Florida College of Medicine
- Drake Morgan
- Department of Psychiatry, University of Florida College of Medicine
- Jae-Sung Kim
- Department of Surgery, University of Florida College of Medicine
- Shinichi Someya
- Department of Aging, University of Florida College of Medicine
- Clayton E. Mathews
- Department of Pathology, University of Florida College of Medicine
- Young Jae Lee
- Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine
- Stephanie E. Wohlgemuth
- Department of Animal Sciences, University of Florida College of Medicine
- Nishanth E. Sunny
- Department of Medicine, University of Florida College of Medicine
- Hui-Young Lee
- Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine
- Cheol Soo Choi
- Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine
- Takayuki Shiratsuchi
- Otsuka Maryland Medicinal Laboratories
- S. Paul Oh
- Department of Physiology, University of Florida College of Medicine
- Naohiro Terada
- Department of Pathology, University of Florida College of Medicine
- DOI
- https://doi.org/10.1038/ncomms14477
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.
