A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Abstract

Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional histidine kinases.