Nature Communications (Jan 2021)

SCISSOR: a framework for identifying structural changes in RNA transcripts

  • Hyo Young Choi,
  • Heejoon Jo,
  • Xiaobei Zhao,
  • Katherine A. Hoadley,
  • Scott Newman,
  • Jeremiah Holt,
  • Michele C. Hayward,
  • Michael I. Love,
  • J. S. Marron,
  • D. Neil Hayes

DOI
https://doi.org/10.1038/s41467-020-20593-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Many computational tools identify mRNA variations by analyzing the transformed RNA-seq data such as collapsed reads. Here, the authors report a computational method which uses shape changes in the RNA-seq coverage profile to discover changes in mRNA expression and alternative splicing.