Transbuccal films in veterinary medicine: a comparative study of the effect of dosage forms on clinical and biochemical parameters of blood

Abstract

In modern veterinary pharmacology and therapy, the ability to control the dosage, delivery, release of the drug, as well as minimal fixation of the animal and absence of post-injection reactions are extremely important. In achieving the goals and successfully implementing pharmacocorrection of animal pathology, the question of improving technological solutions in creation and development of new dosage forms increasingly arises. Transbuccal film can rightfully be considered such a dosage form - it is a convenient system of transbuccal delivery of drugs with controlled release, taken without water, without the use of auxiliary instruments, with minimal time and effort on the part of animal owners and medical personnel. Gelatin film, as an independent carrier of the drug, quickly begins to act upon contact with the moist environment of the oral mucosa, does not require additional fixation and does not have a local irritant effect. It is perfect for patients with dysphagia, vomiting and a number of other functional disorders. The aim of the comparative study of two dosage forms was to identify the possible reaction of the organism and changes in clinical and biochemical parameters of the blood of experimental animals with a course of non-steroidal anti-inflammatory drugs with a single active substance - carprofen. Blood parameters were monitored in 24 dogs from two experimental groups and 10 control animals. When examining the blood of animals in the 2nd experimental group (12 animals) receiving Norokarp in form of tablets for oral administration, leukocytes significantly increased by 4.54%, glucose increased by 1.5 times, and total protein reduced by 4.9% in comparison with the control, which indicated the development of stress hyperglycemia in dogs. Erythrocytes reduced in both experimental groups: by 11% with the drug Carprofen in the dosage form of transbuccal films and by 15% with the drug Norokarp, and the level of hematocrit decreased by 22.5% in animals of the experimental group with the drug Norokarp. The conducted comparative study confirms the advantages of transbuccal form of administration of non-steroidal anti-inflammatory drugs in order to reduce the development of adverse reactions to drugs.

Keywords

• pharmacocorrection
• non-steroidal anti-inflammatory drugs
• carprofen
• pain syndrome