Infectious Diseases and Therapy (Apr 2024)

Seroprevalence and Shifting Endemicities of Hepatitis A Virus Infection in Two Different Geographical Areas in the Philippines

  • Josefina C. Carlos,
  • Vinna Marie T. Quinones,
  • Maria Peñafrancia L. Adversario,
  • Jennifer M. Nailes,
  • Jangail C. Songco,
  • Donaliz R. Garcia,
  • Michelle G. Cacayorin,
  • May Priscilla V. Cero,
  • Maria Paula Aleta Benedicto-Delfin,
  • Ma. Christina C. Blanco,
  • Nadjah S. Natividad,
  • Jacqueline D. Bernabe,
  • Hyacinth Claire T. Chacon,
  • Ronald Alvin C. Ascue,
  • Jayme Natasha K. Paggao,
  • Lous Ohsana P. Comendador,
  • Gustavo Hernandez-Suarez,
  • Adriana Guzman-Holst

DOI
https://doi.org/10.1007/s40121-024-00955-w
Journal volume & issue
Vol. 13, no. 5
pp. 1019 – 1035

Abstract

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Abstract Introduction Infection with hepatitis A virus (HAV) is often asymptomatic in young children, but most adolescents and adults will have symptoms ranging from nausea and tiredness to acute liver failure and even death. The risk of severe disease is higher in older adults and people with pre-existing liver disease. Immunization is recommended in regions with low HAV endemicity levels, i.e., where people get infected later in life. In the Philippines, recent epidemiologic data on HAV infection are lacking. The objective of this study was to assess age-specific seroprevalence and evaluate risk factors associated with HAV seropositivity. Methods People from two geographic areas (urban and rural) were recruited/enrolled and stratified by age group. HAV-specific immunoglobulin G (IgG) antibodies were measured with a chemiluminescent microparticle immunoassay. Sociodemographic parameters, hepatitis medical history, disease knowledge, hygiene measures and sanitation were assessed via a purpose-made questionnaire. Age at midpoint of population immunity (AMPI) was estimated using Kaplan-Meier curves. Logistic regression analyses were carried out to determine factors that were statistically significantly associated (p < 0.05) with HAV seropositivity. Results Overall, 1242 participants were included in the analysis; 250/602 (41.5%) participants from urban regions and 283/640 (44.2%) participants from rural regions tested positive for HAV IgG antibodies. AMPI was 35 and 37 years for the rural and urban region, respectively. Higher education was associated with lower HAV seropositivity prevalence ratios, while not living in the same region for the last 5 years, regularly consuming street food and lack of handwashing after defecation were associated with a higher likelihood of HAV seropositivity. Conclusion Results suggest that HAV endemicity is low in the Philippines. Factors associated with HAV seropositivity were traveling, consuming street food and lack of basic hygienic gestures. Immunization might be an option to protect vulnerable populations against severe hepatitis A disease.

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