Nature Communications (Feb 2023)
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
- Gong-Her Wu,
- Charlene Smith-Geater,
- Jesús G. Galaz-Montoya,
- Yingli Gu,
- Sanket R. Gupte,
- Ranen Aviner,
- Patrick G. Mitchell,
- Joy Hsu,
- Ricardo Miramontes,
- Keona Q. Wang,
- Nicolette R. Geller,
- Cathy Hou,
- Cristina Danita,
- Lydia-Marie Joubert,
- Michael F. Schmid,
- Serena Yeung,
- Judith Frydman,
- William Mobley,
- Chengbiao Wu,
- Leslie M. Thompson,
- Wah Chiu
Affiliations
- Gong-Her Wu
- Department of Bioengineering, James H. Clark Center, Stanford University
- Charlene Smith-Geater
- Department of Psychiatry & Human Behavior University of California Irvine
- Jesús G. Galaz-Montoya
- Department of Bioengineering, James H. Clark Center, Stanford University
- Yingli Gu
- Department of Neurosciences, University of California San Diego
- Sanket R. Gupte
- Department of Computer Science, Stanford University
- Ranen Aviner
- Department of Biology, Stanford University
- Patrick G. Mitchell
- Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University
- Joy Hsu
- Department of Computer Science, Stanford University
- Ricardo Miramontes
- Department of Memory Impairment and Neurological Disorders, University of California Irvine
- Keona Q. Wang
- Department of Neurobiology and Behavior, University of California Irvine
- Nicolette R. Geller
- Department of Neurobiology and Behavior, University of California Irvine
- Cathy Hou
- Department of Bioengineering, James H. Clark Center, Stanford University
- Cristina Danita
- Department of Bioengineering, James H. Clark Center, Stanford University
- Lydia-Marie Joubert
- Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University
- Michael F. Schmid
- Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University
- Serena Yeung
- Department of Computer Science, Stanford University
- Judith Frydman
- Department of Biology, Stanford University
- William Mobley
- Department of Neurosciences, University of California San Diego
- Chengbiao Wu
- Department of Neurosciences, University of California San Diego
- Leslie M. Thompson
- Department of Psychiatry & Human Behavior University of California Irvine
- Wah Chiu
- Department of Bioengineering, James H. Clark Center, Stanford University
- DOI
- https://doi.org/10.1038/s41467-023-36096-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a genetic mutation in the huntingtin gene (HTT). Here, cryo electron tomography provides insights into the morphology of the cells derived from patients with HD and mouse models of the disease.
