Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection

Elias A. Said; Afnan Al-Rubkhi; Sanjay Jaju; Crystal Y. Koh; Mohammed S. Al-Balushi; Khalid Al-Naamani; Siham Al-Sinani; Juma Z. Al-Busaidi; Ali A. Al-Jabri

doi:10.3390/vaccines12010104

Vaccines (Jan 2024)

Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection

Elias A. Said,
Afnan Al-Rubkhi,
Sanjay Jaju,
Crystal Y. Koh,
Mohammed S. Al-Balushi,
Khalid Al-Naamani,
Siham Al-Sinani,
Juma Z. Al-Busaidi,
Ali A. Al-Jabri

Affiliations

Elias A. Said: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman
Afnan Al-Rubkhi: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman
Sanjay Jaju: Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman
Crystal Y. Koh: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman
Mohammed S. Al-Balushi: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman
Khalid Al-Naamani: Department of Medicine, Armed Forces Hospital, P.O. Box 726, Muscat 111, Oman
Siham Al-Sinani: Oman Medical Specialty Board, P.O. Box 1948, Muscat 130, Oman
Juma Z. Al-Busaidi: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman
Ali A. Al-Jabri: Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat 123, Oman

DOI: https://doi.org/10.3390/vaccines12010104
Journal volume & issue: Vol. 12, no. 1
p. 104

Abstract

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Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional study, the associations between different anti-SARS-CoV-2 vaccine SEs and age, sex, the presence of chronic diseases, medication intake, history of allergies, and infections with SARS-CoV-2 were investigated. Our survey used the Google platform and had 866 participants, contacted through e-mails, social media and chain referral sampling (margin of error ≈ 4.38%, 99% confidence). More than 99% of the participants received the BNT162b2 and ChAdOx1-S vaccines. Being female, having chronic diseases, taking medicines routinely and the presence of a SARS-CoV-2 infection (p p < 0.01) were associated with strong SEs after the ChAdOx1-S vaccine second dose. Furthermore, the results reveal, for the first time, the associations between having a history of allergies, chronic diseases, medication usage, and SEs of a strong magnitude for the BNT162b2 and ChAdOx1-S vaccines. Additionally, this study supports the association of the female sex and infection with SARS-CoV-2 with an increased potential of developing stronger SEs with certain anti-SARS-CoV-2 vaccines.

Published in Vaccines

ISSN: 2076-393X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/vaccines

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