PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

Rimma Belotserkovskaya; Elisenda Raga Gil; Nicola Lawrence; Richard Butler; Gillian Clifford; Marcus D. Wilson; Stephen P. Jackson

doi:10.1038/s41467-020-14563-y

Nature Communications (Feb 2020)

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

Rimma Belotserkovskaya,
Elisenda Raga Gil,
Nicola Lawrence,
Richard Butler,
Gillian Clifford,
Marcus D. Wilson,
Stephen P. Jackson

Affiliations

Rimma Belotserkovskaya: Wellcome Trust CRUK Gurdon Institute, University of Cambridge
Elisenda Raga Gil: Wellcome Trust CRUK Gurdon Institute, University of Cambridge
Nicola Lawrence: Wellcome Trust CRUK Gurdon Institute, University of Cambridge
Richard Butler: Wellcome Trust CRUK Gurdon Institute, University of Cambridge
Gillian Clifford: Wellcome Centre for Cell Biology, University of Edinburgh
Marcus D. Wilson: Wellcome Centre for Cell Biology, University of Edinburgh
Stephen P. Jackson: Wellcome Trust CRUK Gurdon Institute, University of Cambridge

DOI: https://doi.org/10.1038/s41467-020-14563-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Although loss of BRCA1 leads to defects in DNA double-strand break repair by homologous recombination (HR) and renders cells hypersensitive to PARP inhibitors, resistance to the drugs can arise. Here the authors reveal that PALB2 chromatin recruitment restores HR in BRCA1-deficient cells depleted of 53BP1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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